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Cancer-induced changes in the PK and PD profiles of several drugs have been documented since the late s Kato et al. Mechanisms of altered drug metabolism in CVDs Failing or hypertensive hearts are susceptible to infiltration by pro-inflammatory cytokines and reactive oxygen species induced by stress Fliser et al. However, due to the fact that HIV infected patients are on highly active antiretroviral therapy HAART consisting of numerous drugs, both, induction and suppression of drug transporters in HIV infection are reported Giraud et al. Falany Index show more. In another study, bilirubin elimination was significantly decreased in collagen-induced arthritis CIA rats compared to normal rats Kawase et al. Jancova et al.
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Hard Bound. New Releases. The authors address several of the major drug metabolizing systems, including the cytochrome P family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases.
Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. Product details Format Hardback pages Dimensions x x Illustrations note Illustrations, black and white; X, p. Other books in this series.
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Developmental and Reproductive Toxicology Ali S. Back cover copy Remarkable advances in molecular and cell biology and the development of novel in vitro model systems have greatly expanded our knowledge of the processes involved in metabolism and transport and led to numerous new therapeutic approaches.
The authors address several of the major drug metabolizing systems, including the cytochrome P family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems. Many chapters contain step-by-step methods for investigating metabolism and transport. Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.
Swanson, Susan D.
Kraner, Soma S. Ray, Martin Hoagland, Earl D. Kim, Kimberley J.
Woodcroft, and Raymond F. Board, M. Anders, and Anneke C. Svensson and David W. Falany Index show more.