The Behavioral Neurology of White Matter

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The behavioral neurology of cerebral white matter. Filley CM(1). Author information: (1)Department of Neurology, University of Colorado School of Medicine. White matter and behavioral neurology. Filley CM(1). Author information: (1) University of Colorado School of Medicine and Denver Veterans Affairs Medical.

The introduction guides the reader engagingly through a history of epilepsy and its context in society before moving on to an extensive discussion of its evolving classification. This discussion is clearly written by a man who has been closely associated with developments in the understanding of epilepsy nosology; brevity is not its greatest virtue.

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The long list of definitions is, similarly, best considered as a reference resource than a read-through. The discussion on research by contrast is easily read, with the writing particularly well handled given the fast moving changes in this field. Dr Engel concentrates on advances in physiological understanding and highlights the uses and limitations of animal models. The phenomenology section is presented with an eye for detail and a perspective that clinical classification provides the starting point for understanding seizure mechanisms.

Descriptions of clinical syndromes are written with authority, demonstrating experience of a wide variety of child and adult seizures syndromes.

[951] Neuropsychology and Behavioral Neurology

In addition to psychiatric comorbidities and psychosocial adaptation, the more controversial areas of personality and mood changes are confronted. Helpful tables in the chapter on general principles of treatment cover interactions between anti-seizure medications, side effects, and dosing schedules. I will be photocopying these for use in clinic!

There are also useful discussions covering management in the elderly, pregnant women and people with comorbid medical, surgical and psychiatric conditions. The beauty of this book is the balance between its clear overview of epilepsy and its mastery of detail on every topic. Admittedly, the writing style is dense in places and a few bullet points might have helped break up the long pages of block text.

Figures, where they appear, are often black and white line diagrams or graphs, of limited explanatory value. The quality of brain image reproduction could have been improved; in particular the many PET scans from the early 80s might have been updated to show colour and higher resolution.

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This book is not for cover-to-cover reading, except for the very stout hearted. It is certainly an ideal reference manual for anyone dealing with the day to day practicalities of epilepsy.

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The relevance of normal and abnormal white matter to behavioral neurology is apparent in every context where this question has been examined: in development, aging, and in a host of diseases, intoxications, and injuries. Since the first edition of this book in , steady advances have been made inunderstanding the neurobiology of white matter and its clinical significance; this edition provides a comprehensive update on this rapidly expanding field. Every chapter has been extensively rewritten, including a comprehensive revision of the account of the neuropsychiatry of white matter, aparticularly challenging area.

The syndrome of white matter dementia is discussed in detail, and its refinement with new information is considered along with the proposal of mild cognitive dysfunction as a precursor syndrome in many clinical settings. In addition, two new chapters have been added, one on the emerging area of white matter changes associated with neurodegenerative disorders such Alzheimer's Disease, and another on neurologic aspects of white matter including intriguing new information on white matter plasticity.

A unifying theme isthe concept of connectivity, as it is clear the white matter forms an essential component of the widespread distributed neural networks by which cognition and emotion are organized.

In addition to the microconnectivity within gray matter that subserves information processing, the macroconnectivityof white matter enables information transfer - both are critical for the functions of the human mind. Christopher M. Je suis Heures de jeu :. The Neurological BackgroundI. The Perspective of Behavioral Neurology2.

White Matter Structure and FunctionI.

Computed TomographyII. Magnetic Resonance SpectroscopyIV.

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Myelinated fibers perform a critical role in normal brain function by virtue of this vast and intricate connectivity. In the two decades since the advent of MRI, enormous strides have been taken in the understanding of white matter and its disorders. The depolarization so produced is then quickly reversed by a rapid efflux of potassium ions that restores the resting potential. Visualizing the mind. The origin, termination, course, and interdigitation of white matter tracts remain largely obscure; therefore, the function of these tracts can only be inferred in tentative terms.

Magnetization Transfer ImagingV. Diffusion Tensor ImagingVI. Functional NeuroimagingVII. Mapping Neural Networks4. Development and AgingI.

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Development of White MatterII. White Matter Changes in Aging5. Demyelinative DiseasesI. Multiple SclerosisII. Neuromyelitis OpticaIII. Acute Disseminated EncephalomyelitisIV. Schilder's DiseaseV. Marburg's DiseaseVI. Tumefactive Multiple Sclerosis7. Subacute Sclerosing PanencephalitisIV.

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Progressive Rubella PanencephalitisV. Varicella Zoster VasculopathyVI. Cytomegalovirus EncephalitisVII. Lyme Encephalopathy8.

UC Davis neurology researchers focus on brain's superhighway of connectors

Inflammatory DiseasesI. Systemic Lupus ErythematosusII. Behet's DiseaseIII. Sj"gren's SyndromeIV. Wegener's GranulomatosisV. Temporal ArteritisVI. Polyarteritis NodosaVII. Toxic LeukoencephalopathyI. Therapeutic DrugsIII. Drugs of AbuseIV. Environmental ToxinsV. The Spectrum of Toxic Leukoencephalopathy Metabolic DisordersI. Cobalamin DeficiencyII. Folate DeficiencyIII.